Life extension theraphies and more

[scott]

They are also used to make a виник (translation vine, but its like a broom) here in Russia. Used in the sauna to slap the skin, opening/cleaning pores, increasing circulation. I tried it and was asked if it itches, it didn't itch. Was told it will itch in three days, which it did, but not in a bad way.

Don't have to cultivate it here, just look for some. We too use it to make nutritious water for our garden. Haven't tried eating it yet!

[Yodean]

In my case, I always eat nettles fresh, from my garden directly to my kitchen. I suppose the dried leaves have the

I just received this in the mail:

https://www.amazon.ca/dp/B0818Z9K16?psc ... ct_details

I'm too lazy to make the nettle extract myself, so what do peeps who've used nettle extract previously think? It looks promising.

@bpcw: apparently nettle extract can help with seasonal allergies, among many other purported benefits;

Ninjedi Biohacking Experiment 666 with nettle extract starts today ... will report back sometime in the future with preliminary results.

[SOL]

@Stefk Since you enjoy sports that involve movement and you seem knowledgeable about ancient Indian and other Asian exercises, workouts, and rituals, you might find this video interesting
https://youtu.be/nemG0KYCW5w

[stefk]

Yes Sol, I enjoy asian exercices, because all these movements all multiplanar. But i also appreciate some westerner exercices, like the kalos sthenos or hebertism (parkour), also boxing for cardio.

But for me, the king of movements come from the kalaripayat, the martial yoga.
I cannot find an instructor here, but its possible to practice the meipayattu, the training without weapons, only to keep the body and the brains fit and alert.

Iruthy kaal, kick and sit, is one of the best warming ups, you can practice, every time before your workout. Two simple but not easy exercices, elegant but full of power. I have noticed that all these exercices are well suited for tall people.

https://youtu.be/6UJvqBEviTI

[stefk]

Do you knox the PRAL table ?

To stay healthy, its important to maintain a good alkaline acidic balance in the body.

Lynus Pauling, the unique double nobel prices in the world, already noticed the importance of this balance, to

prevent cancer. To much acidic body is not good.

https://inaturally.com.au/wp-content/up ... -Table.pdf

Notice, parsley dried, the champion of alkanisation. Good idea to put parsley dried on the salad, everyday.....

[bpcw]

Do you knox the PRAL table ?

To stay healthy, its important to maintain a good alkaline acidic balance in the body.

Lynus Pauling, the unique double nobel prices in the world, already noticed the importance of this balance, to

prevent cancer. To much acidic body is not good.

https://inaturally.com.au/wp-content/up ... -Table.pdf

Notice, parsley dried, the champion of alkanisation. Good idea to put parsley dried on the salad, everyday.....

Interesting, may purchase some.

[stefk]

these last decades, scientists have conducted tons of scientific researches and experiences about the effects

of exercices and sport on endocrinal system.

https://pmc.ncbi.nlm.nih.gov/articles/PMC9124654/

its a compilation of 33 studies, with 10 sudies about the effects of HIIT, hifh intensity interval training.

some very interesting results,

"""HIIT improves insulin sensitivity, body composition and cardiovascular health [76], and several studies suggest the increase in insulin sensitivity due to exercise training is directly proportional to exercise intensity and volume """

"""There were larger increases in total testosterone SHBG when HIIT was used as the exercise protocol, suggesting increases in free testosterone [63]. ""


These studies prove for me, the best method of training is HIIT, with a personal preference for tabata.

[SOL]

TABATA is closely related to something I’ve discussed here and in the market update a couple of times, though I can’t recall which section of this forum it was under. The concept is simple but intense: you push yourself to your absolute limit for 30 seconds, then rest for 90 seconds. This cycle is repeated for 9 sets, and you're done for the day.

You can target three different muscle groups__ 3 sets to each. The next day, you switch to another set of muscles. It takes about 18 minutes from start to finish, but the actual workout time is only 270 seconds of all-out effort. Despite the brevity, it’s incredibly challenging, and most beginners struggle to even complete 5 sets.

[stefk]

Yes Sol, but the classic tabata ( japanese sport coach during the years 90) is 20 sec heavy workout, 10 sec rest, X 8.

Before it, 10 min warming up, and at the end 10 min cooldown. Maximum three times per week.

You can of course modulate this receipt for your personal tastes. You can do 30sec workout 30 sec rest, or 30 90,

my personal formule is 20 20. The results are tremondous after three mounths.

[stefk]

I think I am the first one to post in 2025. I wish a Happy healthy new year for everybody, a year full of good sweat, set healthy training goals for this new year, if you set goals, set them big ......

[SOL]

I think I am the first one to post in 2025. I wish a Happy healthy new year for everybody, a year full of good sweat, set healthy training goals for this new year, if you set goals, set them big ......

Happy New Year and agree 1000%

It's better to set ambitious goals and miss them than to aim low and achieve them. As Michelangelo said, "The greater danger for most of us lies not in setting our aim too high and falling short; but in setting our aim too low, and achieving our mark."

[stefk]

Hello girls and guys. Its a pity, this file is almost dead, when I reread all the pages of this file, I realize it could be the most important one of this forum. And all these ancient interesting contributors who disappeared of the landscape !!!!

Enfin soit, I discovered a very important study, a recent one, from december 2025.
A UK scientific team from Newcastle, proved with this study, that HIIT fitness protocol can cure cancer !!

Yes, its a very serious info, we have now the scientific prove that a good fitness session acts like a real medication against colorectal cancer.

https://www.ncl.ac.uk/press/articles/ar ... welcancer/

"""The study involved 30 volunteers, male and female aged 50–78, all overweight or obese (a risk factor of cancer) but otherwise healthy.

After completing a short, intense cycling test lasting approximately 10 minutes, researchers collected blood samples and analysed 249 proteins. As many as 13 proteins increased after exercise, including interleukin-6 (IL-6), which helps repair the DNA of damaged cells."""

"""Dr Orange, a Clinical Exercise Physiologist at The Newcastle upon Tyne Hospitals NHS Foundation Trust, said: “These results suggest that exercise doesn’t just benefit healthy tissues, it may also create a more hostile environment for cancer cells to grow."""

[stefk]

All the details of this new study are here

https://onlinelibrary.wiley.com/doi/10.1002/ijc.70271

If HIIT can cure cancer, its loogical to admit it can also prevent cancer.

What we can learn from this study : the physical test happened in the morning between 8 and 10 o'clock, with an empty stomach, after the night fasting. The duration was 10 minutes till exhaustion.

Conclusion for us, the best moment to train is in the morning after the night fasting, with empty stomach.

Best training protocol would be, the tabata interval training. I do 4 rounds of 4 minutes, with 4 different exercices of 1 minute for each exercice, each round separated by 2 to 3 minutes. Each round till exhaustion.
And of course before it, a good warming up of 5 minutes, and after it, a good cooldown of 10 minutes.

The best training for a tactical investor.

[SOL]

I have a strong interest in this topic and access to a substantial amount of research and data, so I will likely post here more frequently and keep the discussion open. You are absolutely right that health is the ultimate form of wealth. Without good health, most other forms of wealth lose much of their value. That is, of course, my personal opinion and not one I intend to impose on anyone. Overall, the information you posted is excellent.

The Newcastle study was particularly interesting, though it is important not to overstate the findings. The study did not demonstrate that exercise can cure all cancers. What it did show was that a single bout of intense exercise altered blood proteins in ways that may create a less favourable environment for colorectal cancer cells while simultaneously improving DNA repair mechanisms. That is a promising finding, but it is a long way from proving a cure for cancer.
https://pmc.ncbi.nlm.nih.gov/articles/PMC12236277/

That said, if one focuses on reducing inflammation, the potential benefits become far broader. Virtually every chronic disease shares at least one common characteristic: the body is in a state of dis-ease, and that state is almost always associated with elevated levels of inflammation. If we wanted to refine the focus even further, the goal should be reduced inflammation, improved metabolic health, stronger immune function, and lower all-cause mortality. Those are outcomes that influence almost every major category of disease.
Here are several additional interventions and therapies worth considering, some of which you already mentioned.

1. HIIT and FIT Training
The Newcastle study found significant increases in several exercise-responsive proteins, including IL-6, following a short high-intensity exercise session. Researchers suggested that exercise may help create a more hostile environment for cancer growth while simultaneously supporting DNA repair processes.

A 2025 meta-analysis involving colorectal cancer patients found that structured exercise training reduced inflammatory markers, including C-reactive protein (CRP), while also improving body composition. This is important because chronic inflammation remains one of the primary drivers of aging and many chronic diseases.
https://www.frontiersin.org/journals/nu ... 12674/full

The implications extend far beyond cancer prevention:
• Reduced systemic inflammation
• Improved insulin sensitivity
• Better mitochondrial function
• Enhanced cardiovascular health
• Lower risk of multiple age-related diseases

Many longevity researchers now view exercise as the closest thing we currently possess to a broad-spectrum anti-aging intervention. It is not a pill, it is not a supplement, and it is certainly not glamorous, but the data supporting its benefits continues to grow stronger with each passing year.

2. Taurine

Taurine became one of the most discussed longevity molecules after the publication of a landmark paper in Science during 2023.

Researchers observed that taurine levels declined with age in mice, monkeys, and humans. Supplementation was associated with a number of favourable outcomes, including:
• Increased lifespan in mice
• Improved healthspan in monkeys
• Reduced cellular senescence
• Reduced DNA damage
• Improved mitochondrial function
• Reduced age-related inflammation, often referred to as inflammaging
https://pmc.ncbi.nlm.nih.gov/articles/PMC10630957/

Researchers also noted that taurine levels tended to increase following endurance exercise, which raises an interesting possibility. Some of the benefits attributed to taurine supplementation may overlap with pathways already activated by regular physical activity.

As encouraging as these findings are, the story is far from settled. Newer studies published in 2025 challenged the notion that taurine deficiency is a primary driver of human aging.
https://www.nature.com/articles/d41586-025-01747-z

That conclusion actually makes sense. Supplements rarely compensate for an unhealthy lifestyle. If poor metabolic health, chronic inflammation, lack of exercise, poor sleep, and excessive stress remain unaddressed, no supplement is likely to produce transformative results. At best, supplements tend to amplify an already solid foundation. They are rarely capable of replacing one. This is one of the biggest mistakes people make. They search for a miracle molecule while ignoring the factors that caused the damage in the first place.

3. NMN (Nicotinamide Mononucleotide)
NMN has attracted considerable attention because it serves as a precursor to NAD+, a molecule involved in several critical biological processes, including cellular energy production, DNA repair, mitochondrial function, and overall cellular resilience.

A number of human studies have reported improvements in insulin sensitivity, aerobic capacity, and several metabolic markers following NMN supplementation. While claims regarding lifespan extension in humans remain unproven at this stage, the broader relationship between metabolic health and longevity is difficult to ignore. Individuals who maintain optimal metabolic health generally live longer and experience lower rates of chronic disease.

As with most supplements, NMN should probably be viewed as a supporting actor rather than the star of the show. Exercise, sleep, diet, and metabolic health remain the primary drivers. Supplements may help optimise an already solid foundation, but they rarely compensate for a poor one.

4. Sauna and Far Infrared Sauna

Sauna use possesses one of the strongest observational records in the longevity field. A 20-year Finnish study that followed more than 2,300 men found that individuals who used a sauna frequently experienced substantially lower rates of cardiovascular mortality and lower all-cause mortality compared with infrequent users.
https://www.health.harvard.edu/blog/sau ... 1502257755

Far infrared sauna studies suggest a number of potential benefits, including improved endothelial function, lower blood pressure, reduced oxidative stress, enhanced circulation, and improved cardiovascular performance.
https://pmc.ncbi.nlm.nih.gov/articles/PMC2718593/

Researchers have proposed that repeated heat exposure functions as a mild hormetic stressor, much like exercise. In simple terms, the body responds to manageable levels of stress by becoming more resilient and adaptive over time.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5941775/
The pattern should sound familiar by now. Whether it is exercise, cold exposure, fasting, or heat exposure, the body often becomes stronger when exposed to controlled stress followed by adequate recovery.

5. Hanging and Grip Strength

While direct longevity studies examining hanging itself remain limited, grip strength has emerged as one of the strongest predictors of healthspan, functional capacity, and all-cause mortality. Regular hanging may help improve shoulder mobility, promote spinal decompression, increase grip strength, and strengthen connective tissue throughout the upper body. Large population studies consistently show that individuals with stronger grip strength tend to experience better health outcomes and lower mortality rates.

Many longevity physicians now view grip strength as a practical biomarker of biological aging.
This is one area where simplicity works in your favour. One does not need expensive equipment, complicated protocols, or endless optimisation. Start slowly and progress gradually. Even two minutes per day can make a difference. Personally, I try to hang at least three times a day, sometimes longer when time permits. The improvement in flexibility, shoulder comfort, and grip strength has been noticeable.

6. Zone 2 Cardio
High-intensity training receives most of the attention, but Zone 2 training has quietly become one of the cornerstones of modern longevity medicine.
The benefits include:
• Increased mitochondrial density
• Improved fat metabolism
• Reduced inflammation
• Better cardiovascular efficiency
• Improved insulin sensitivity

Ideally its best to combine both rather than relying exclusively on high-intensity exercise.
• 80% Zone 2 aerobic training
• 20% HIIT training

Zone 2 cardio refers to sustained, moderate-intensity exercise performed at roughly 60-70% of your maximum heart rate. The simplest way to identify it is through the conversation test. You should be able to carry on a normal conversation without gasping for air, but singing a song would quickly become difficult.

Typical examples include brisk walking on an incline, easy jogging, cycling at a steady pace, swimming continuous laps, or rowing at an effort that feels sustainable rather than punishing. The objective is not exhaustion. The objective is maintaining a consistent workload for an extended period while generating minimal recovery demands.

For most individuals, maximum heart rate can be estimated using the formula 220 minus age, with Zone 2 generally falling between 60% and 70% of that figure. The reason Zone 2 has become so popular among longevity researchers is that it improves multiple systems simultaneously. It increases both the number and efficiency of mitochondria, improves insulin sensitivity, enhances fat utilisation, strengthens cardiovascular function, and does so without creating the recovery burden associated with harder forms of training.
7. Resistance Training
Among all available interventions, resistance training may be the most underrated longevity tool.
The benefits extend far beyond appearance and include:
• Increased muscle mass
• Improved insulin sensitivity
• Reduced fall risk
• Improved bone density
• Lower mortality risk

Muscle is not simply a tool for movement. It functions as a metabolic organ that influences glucose regulation, hormone balance, energy metabolism, and overall resilience.
One of the strongest predictors of healthy aging is the ability to maintain muscle mass and strength as the years pass. Individuals who preserve muscle tend to remain more independent, recover better from illness, and maintain a higher quality of life.

8. Morning Exercise While Fasted

The Newcastle protocol was performed following an overnight fast. While fasting itself was not the primary focus of the study, exercising in a fasted state may increase fat oxidation, improve metabolic flexibility, and enhance insulin sensitivity.

The evidence remains mixed, but many individuals find that morning fasted training improves adherence and overall metabolic control. Ultimately, the primary benefit still comes from the exercise itself.
One of the easiest ways to incorporate fasting into your routine is to eat your final meal around 7 or 8 p.m., train first thing in the morning, take a cold shower afterwards if you enjoy it, and then wait until at least 12 hours have elapsed before eating again.

The beauty of this approach is that most of the difficult part occurs while you are asleep. If you sleep for roughly eight hours, you are already two-thirds of the way through a 12-hour fast before you even begin thinking about food.

The fasting period, combined with exercise, helps activate AMPK, one of the body's primary energy-sensing pathways. AMPK is associated with improved metabolic efficiency, enhanced fat utilisation, better insulin sensitivity, and improved mitochondrial function. At the same time, fasting temporarily suppresses mTOR activity, allowing the body to shift away from growth and toward maintenance and repair. Once the fast is broken, particularly with a protein-rich meal, mTOR activity rises again to support recovery, muscle preservation, and adaptation.

As for the cold shower, exposure to cold appears to increase norepinephrine levels, improve stress resilience, stimulate brown fat activity, and may enhance metabolic flexibility. Much like heat exposure and exercise, cold exposure appears to work through the principle of hormesis, where small, manageable doses of stress stimulate stronger biological responses over time.