Life extension theraphies and more

[SOL]

This thread is being continued from here as the this topic is completely different
viewtopic.php?f=2&p=3433#p3433

]

SOL - In the U.S. anything that is "all natural", "herbal", homeopathic generally don't have restrictions. Of course, as I expressed before I think 99.999% of such products are complete "snake oil" without double blind science to back them up so I could never make a living in them. I am curious about NAD+ but I suspect that is also snake oil.

SOL - the only thing I know that scientists consider credible in terms of extending life is to limit calorie intake. Even exercise has not really been proven to extend life (not scientifically with absolute certainty last I checked).

Most of today's science and scientific journals fall under the category of pseudoscience. COVID clearly confirmed this. However, calorie restriction is not the only therapy that extends life. The reasoning behind calorie restriction is simple. When you eat less you put fewer toxins in your system. I forgot the study that I read that illustrated food that was completely free of any toxins and the mice lived just as long as the calorie-restricted mice.

Additionally for example Metformin has been shown to mimic the effects of those on a calorie-restricted diet.

Logically speaking the way to extend life is to keep the inflammation markers down. i doubt a long term study will be done on this, but if you were to stay on a diet that kept most inflammatory agents under control, it would definitely produce a life-extension benefit.

For the record life extension and good health so as to speak are hobbies or areas of interest and I spend a lot of time researching the topic. In the beginning I would spend up to 45 hours a week on research but that was years ago when i was just getting started

Drugs that could extend life span


One of the most promising groups of drugs is based on a compound called rapamycin. It was first used to suppress the immune system in organ transplant recipients, then later found to extend lifespan in yeast and worms. In 2009, mice were added to the list when the drug was found to lengthen the animals’ lives by up to 14 per cent, even though they were started on the drug at 600 days old, the human equivalent of being about 60.

They gave 218 people a six-week course of everolimus, followed by a regular flu vaccine after a two-week gap. Compared with those given a placebo, everolimus improved participants’ immune response – as measured by the levels of antibodies in their blood – by more than 20 per cent, to two out of the three vaccine strains tested.

Of the three everolimus doses tested, the highest caused fatigue and mouth ulcers, while two lower doses had no apparent ill effects. Previous experiments in mice with rapamycin suggest this class of drug acts by inhibiting a protein called mTOR. mTOR also seems to be affected by calorie restriction – the strategy of trying to live longer by eating less

There have been no trials of metformin as a longevity drug in people, but a recent study hinted that it might have a similar effect. The study was designed to compare metformin with another diabetes medicine, using records of 180,000 UK patients. To tease out the differences between the drugs, people who started taking them were compared with people without diabetes who had been closely matched for age and other health factors, and tracked over five years.

Surprisingly, diabetics taking metformin were not only less likely to die in that time than those on the other medicine but they were also about 15 per cent less likely to die than people without diabetes who took neither drug. “This shows we already have a drug that we can potentially use in humans,” says Nir Barzilai, who heads the Institute for Aging Research at the Albert Einstein College of Medicine in New York.

https://www.newscientist.com/article/mg ... s-of-life/



n mice, disruption of the angiotensin II receptor increases lifespan. Not only that, but the increase is large, as large as that caused by insulin receptor disruption. See chart below.

Knocking-out AT1A prolongs life span in the mouse. A Kaplan-Meier an...

The average lifespan of normal mice was 24 months, that of genetically disrupted angiotensin receptor knockout mice was 31 months, about a 26% increase. When all the wild-type animals had died, 85% of the knockout mice were still alive. Body weights and physical activity between the two groups were the same, so this was not an artifact of reduced food intake, i.e. calorie restriction. (Many life-extension treatments appear to work by inducing lower food intake.)

However, another study found that long-term angiotensin inhibition resulted in less fat tissue.

In rats, long-term angiotensin blockade exerts “a significant protective effect on the function and structure of the cardiovascular system in all treated animals.” Of interest, the animals were divided into 3 groups: control (no treatment), a group treated with an ACE inhibitor, and a group treated with an AR blocker. There was no difference between the 2 treatments, which “clearly indicates that most of the effects are exerted through AT1 receptors. An outstanding finding was the significant and similar prolongation of life span in both groups of treated animals compared with untreated control animals.” The average survival of the control group was 735 days, while the two treatment groups lived 892 and 877 days, respectively, a large effect.

So, can you get all the effects of calorie restriction just by inhibiting the angiotensin system? Could be, yes.

“…both animal and human evidence show that RAS blockade can prevent age-related structural and functional alterations in several organs, progression to the metabolic syndrome, the development of diabetes, hypertension and some of its consequences, cardiovascular changes, and cerebral and cognitive impairments. The latter conditions act as surrogate markers of the ageing process, and at the same time, they accelerate age-related structural and functional decay in various tissues.”

https://roguehealthandfitness.com/blood ... -lifespan/



How does RTB101 circumvent aging? We've arrived at the part of the story that reads like a scientific detective novel — a tale with some remarkable thrills and chills.

Drugs like RTB101 work by inhibiting an enzyme in the mTOR pathway, a basic process that regulates growth and metabolism in cells. As we get older, part of this pathway, TORC1, seems to rev up a bit. That's bad. “More TORC1 activity seems to be associated with age-related health problems,” Mannick says. The drugs throttle it back. “It works the same way calorie restriction and intermittent fasting work. In aging studies in animals, cutting back on calories increases life span. But that's difficult for people to do for decades. Inhibiting TORC1 this way seems to do the same thing, without the dieting."

Scientists discovered mTOR while studying rapamycin, a drug that is used today to prevent rejection in some organ transplants and cancer. In fact, mTOR is short for “mammalian target of rapamycin.” But rapamycin almost landed in a pharmaceutical-company trash can in the 1980s.

Along the way, scientists realized rapamycin “didn't really look like any other drug,” one researcher recalled. “Its pattern of activity was unique.” One weird trick: This Easter Island ooze made fruit flies, worms and yeast cells live longer.
"We are rigorous about making sure the conditions are exactly the same at all three labs: the same food, the same water, the same lab temperatures, the same training for lab technicians,” Miller says. “The doors are kept locked; only people working on the study can enter. The goal is to be sure mouse longevity-study results are reproducible. So often in the past, an exciting study in one lab could never be repeated anywhere else. We're also notable because we publish all of our results, whether a compound extends longevity or not.” So far, only a few compounds have shown promise — with rapamycin the strongest.

https://www.aarp.org/health/drugs-suppl ... aging.html


RTB101, an investigational therapy being developed to treat Parkinson’s disease, is well-tolerated, can cross the blood-brain barrier, and reaches potentially therapeutic concentrations in cerebrospinal fluid (CSF), according to interim results of a Phase 1b/2a study.

Developed by resTORbio, RTB101 is an orally-administered compound meant to induce autophagy in neuronal cells by inhibiting a protein called target of rapamycin complex 1 (TORC1).

Autophagy is the process by which cells clear away defective and unnecessary components, such as toxic misfolded protein aggregates. This process is vital to cellular health and survival, and defective autophagy is thought to contribute to the progression of Parkinson’s disease.

A key clinical finding in Parkinson’s is the presence of protein aggregates called Lewy bodies in dead and dying nerve cells.

Multiple preclinical models have shown that TORC1 inhibition alleviates the symptoms of neurodegenerative diseases, including Parkinson’s.

“Preclinical data suggest that induction of autophagy has the potential to slow the progression not only of Parkinson’s disease but also of multiple other neurodegenerative diseases that are characterized by the accumulation of toxic protein aggregates in cells such as Huntington’s and Alzheimer’s disease,” Joan Mannick, MD, co-founder and chief medical officer of resTORbio, said in a press release.

To date, three separate treatment cohorts in the trial have shown evidence that RTB101 reaches concentrations that inhibited TORC1 activity and induced autophagy in neuronal cells in preclinical models.
https://parkinsonsnewstoday.com/2020/02 ... m-results/


We tested about 20 medications for the ability to extend life span in C elegans.4 We chose drugs with a variety of structures and indications for use in human beings. Most of these drugs previously had not been proposed to affect aging. For example, we selected 1 benzodiazepine (flurazepam dihydrochloride), 1 diuretic (furosemide), 2 glucocorticoids (prednisone and betamethasone 17-valerate), 1 phenothiazine derivative (fluphenazine dihydrochloride), and 2 gonadal hormones or inhibitors (β-estradiol and mifepristone).

For each drug, we typically analyzed about 50 worms for each of 3 concentrations. Caenorhabditis elegans were cultured on Petri dishes containing nutrient agar and bacteria for food, and medications were added to the agar so the worms would ingest the drug. Worms were cultured with the drug for their entire lives, from conception until death. Most of the drugs had no effect on life span or caused substantial shortening of life span at the highest dosage, demonstrating the specificity of this assay.

Ethosuximide caused a significant increase in C elegans life span, extending mean adult life span from 16.7 days to 19.6 days, a 17% increase (Figure 1A and B). Furthermore, it delayed several age-related degenerative changes.4 Compared with untreated control worms, worms treated with ethosuximide exhibited persistence of 2 neuromuscular activities: pharyngeal pumping and the well-coordinated sinusoidal body movement characteristic of youth. In addition, we recently observed that ethosuximide can delay age-related degeneration of reproductive function, a physiologic function of nonneuronal cells (S. Hughes, PhD, and K.K., unpublished data).

Ethosuximide is a small heterocyclic ring compound that prevents absence seizures in human beings11 (Figure 1A). We hypothesized that the anticonvulsant activity in human beings and the life span extension activity in worms might have a similar mechanism. To investigate this possibility, we tested several compounds with structural and functional similarities to ethosuximide for the ability to extend life span in C elegans. Trimethadione and 3,3-diethyl-2-pyrrolidinone have structures similar to that of ethosuximide, and both compounds have anticonvulsant activity in vertebrates11,12 (Figure 1A). These drugs caused a significant extension of mean and maximum life span (Figure 1C and D). Succinimide, similar in structure but lacking anticonvulsant activity in vertebrates, did not extend life span in C elegans (Figure 1E). These correlations between anticonvulsant activity and life span–extending activity suggest that ethosuximide, trimethadione, and 3,3-diethyl-2-pyrrolidinone extend life span by means of a similar mechanism that may be rela


Ethosuximide and trimethadione treatments have potent effects on the human central nervous system. In C elegans, ethosuximide and trimethadione modified several neuromuscular behaviors in young adults. These drugs caused hyperactive locomotion and stimulated egg laying.4 These drugs also increased the sensitivity of young adult worms to an acetylcholinesterase inhibitor, which suggests that they affect synaptic transmission. The ability of these AEDs to modify C elegans neural activity has 2 important implications. First, it provides further evidence for the hypothesis that the life span extension in worms and the anticonvulsant activity in human beings have a similar mechanism. Second, it suggests that the drugs extend life span by altering neural activity, which indicates that neural activity controls aging and life span. We discuss this intriguing idea in the final section of this article.

https://jamanetwork.com/journals/jamane ... cle/790945


DILANTIN


Dilantin (phenytoin or diphenylhydantoin) is an age-retarding therapy that has received alot of press over the years mainly due to the work of Jack Dreyfus, the founder of the Dreyfus Mutual Funds. Dreyfus had long suffered from severe depression, which Dilantin cured so successfully that Dreyfus created a medical foundation in order to tell the world about its many benefits.

FDA approval exists only for its use as a treatment for epilepsy.

Dilantin presumably works by its ability to stabilize electrical activity in cell membranes. Because of this some of the benefits of Dilantin are:
* Greater learning ability
* Decreased aggression
* Enhanced long term memory
* Increased Intelligence
* Improved verbal performance

https://sites.google.com/site/lifeexten ... t/dilantin

[Yodean]

Additionally for example Metformin has been shown to mimic the effects of those on a calorie-restricted diet.

Logically speaking the way to extend life is to keep the inflammation markers down.

In fact, mTOR is short for “mammalian target of rapamycin.”

Autophagy is the process by which cells clear away defective and unnecessary components, such as toxic misfolded protein aggregates. This process is vital to cellular health and survival, and defective autophagy is thought to contribute to the progression of Parkinson’s disease.

“Preclinical data suggest that induction of autophagy has the potential to slow the progression not only of Parkinson’s disease but also of multiple other neurodegenerative diseases that are characterized by the accumulation of toxic protein aggregates in cells such as Huntington’s and Alzheimer’s disease,” Joan Mannick, MD, co-founder and chief medical officer of resTORbio, said in a press release.

Putting on Young Anakin’s Level 3 hat for a brief moment, here are some initial thoughts:

(1) Metformin:

This drug has been around for a long time and is fairly effective and safe for use in mild to moderate type 2 diabetics, with some promise for improving longevity in healthy subjects.

With that said, one should consider a few questions before getting too excited.

Although fairly rare, some who take metformin develop renal and hepatic dysfunction. In addition, there are concerns about metformin causing a certain degree of mitochondrial toxicity. Mitochondria are the energy factories of most of our cells, and thus play an important role in longevity.

Even if metformin is effective in improving longevity in healthy human subjects, what is the dose x duration required, the magnitude of effect? How are these factors affected by gender, age, weight, body fat composition, etc.?

For instance, what if a healthy person, on average, needs to take metformin 500mg twice daily for 33 years to gain, on average, an extra 3.33 days of life? To me, that would not be enough to make it worthwhile. Also, when does one start taking it? When one is 12-years-old? Or 60? If you are still alive at 80, should you continue taking it? Etc.

(2) mTOR pathway:

There is a lot of exciting research currently being performed involving the mTOR pathway. At some risk of oversimplification and for the sake of relative brevity, the mTOR pathway may be conceptualized as a sort of “switch” between an internal milieu of “comfort and growth,” as opposed to one of increased physiological challenge.

For example, eating a large meal containing large amounts of protein and carbohydrates will turn on the mTOR switch (fat does not turn on the mTOR pathway very much), likely through insulin levels spiking. There is some necessity for this as when the mTOR pathway is “on,” tissue growth may occur more easily, among other anabolic physiological processes. So you do need the mTOR pathway to be activated some of the time.

The main challenge is that your typical modern human eats too much, too often, and generally low-quality food. This results in the mTOR pathway being “on” far too often. Having the mTOR pathway activated too much is associated with higher incidences of cancer (pre-cancerous cells get the “growth boost,” or stimulation, that the activated mTOR pathway offers), obesity, diabetes type 2, etc.

However, the mTOR pathway is a diffuse physiological system that has presumably evolved over millennia for human survival. Trying to develop a synthetic pharmaceutical agent to interfere with this extremely robust pathway will most likely lead to unintended, harmful downstream effects.

There are natural ways to “shut off” or reduce activation of the mTOR pathway which has stood the test of time.

One of them is intermittent fasting (IF). For most healthy individuals, simply fasting for 16+ hours will start to turn off the mTOR pathway. Exercise will also tend to synergize the effects of IF, so if you combine exercise with IF, the effects on mTOR will be even more profound.

(3) Autophagy:

Autophagy, or autophagocytosis, literally means “eating of self” (from the cell’s perspective). It is somewhat related to apoptosis (a normal, genetically regulated process leading to the death of cells and triggered by the presence or absence of certain stimuli, such as DNA damage).

In essence, certain branches of your immune system survey for damaged, old or abnormal cells, and “eat” them, or destroy them, and recycle some of the usable parts. Pretty fascinating stuff – yet another reason to optimize one’s immune system whenever possible.

Autophagy is responsible for “cellular cleansing,” as well as eliminating pre-cancerous cells before they can accumulate more DNA abnormalities, grow, and develop into “full-blown” clinical cancer.

In some ways, one may view autophagy/apoptosis as the antithesis of activation of the mTOR pathway.

When the mTOR pathway is highly activated (there may be different degrees of activation in different areas of one’s body), autophagy/apoptosis is largely absent. And vice versa.

So you need a balance of autophagocytosis and mTOR activation at different times for optimum health.

Once again, the systems of autophagy in humans developed over millennia for our survival. Trying to develop a novel pharmaceutical agent that would be able to mimic the effects of autophagy in healthy individuals without side effects may be close to impossible.

And once again, intermittent fasting is a natural means of inducing autophagy. The longer one does IF, the more the autophagocytosis system is activated.

There are some prominent scientists who believe that healthy individuals who fast three to seven days every three to four months will virtually eliminate their risk of developing cancer. They are drawing this conclusion from animal studies, naturally, but the basic theory is that by inducing a high degree of autophagy through fasting on a regular basis, one is eliminating all the pre-cancerous cells that may be present in one’s body at any given time.

(4) Inflammation:

While it is true that most degenerative and disease processes involve some degree of inflammation somewhere in their respective pathways (usually a common end point), it is important to differentiate between “acute” and “chronic” inflammation.

Indeed, chronic inflammation is generally harmful, almost without exception.

The same is not true for certain acute inflammatory processes, which are essential to human survival.

As one example, let us consider the example of someone who punches a nearby window after learning his highly leveraged options position on BTC dropped by over 88% overnight. The bleeding from the dozens of cuts on his hand requires certain coagulation pathways to be activated, as well as acute inflammatory processes local to the sites of injury, to prevent subsequent infection and catalyze healing.

Another instance is exercise. Various studies have been done on healthy marathon runners just after a race. Their bloodwork in terms of inflammatory parameters (e.g. markers like CRP, ESR, platelet count, TNF [tumor necrosis factor] etc.) is eerily similar to those who are seriously sick from systemic sepsis, including those extremely rare patients with “cytokine storm” from cv19. The difference, of course, is that the levels of the inflammatory markers in the healthy marathon runners rapidly normalize.

Once again, intermittent fasting has been found, in small human studies, to lower inflammatory markers.

Other natural modalities that have shown benefit in small human studies (one needs to really search for them, but they can be found) to lower inflammatory markers like TNF (tumor necrosis factor) include the Wim Hof Method, as well as various forms of cold exposure.

[Triplethought]

Spring Chicken by Bill Gifford is supposed to be a great overview of this topic. I notice the audio book is free...gonna get it since that's my favorite price.

https://www.amazon.com/Spring-Chicken-B ... 156&sr=8-4

[stefk]

Whatever nectar flows from the moon which is divine form, it is all swallowed up by the sun. Hence the body decays.

There exists a divine process by which the sun is duped…

If one’s navel is high and palate is low, then the sun is above and the moon below. This position, the inverted pose (Viparita Karani), is to be learned through the instructions of a Guru.

Hata Yoga Pradipika III, 77-79
.............................

This is the king of the asanas.

The ancients yogis discovered a simple method to slow the body decay. These ancients had no political agenda, no financial agenda, they had no reasons to lie, we can trust them.......

[SOL]

The links posted above were intended to provide general information that there are possible strategies to slowing the ageing process.

One can get the same benefits from intermittent fasting without fasting by eating high-quality food. I lost the link but research was conducted that showed one of the main reasons intermittent fasting worked was because by eating less one reduced the amount of toxins one ingested due to the low quality of our food supply. Fasting stresses out the body and increases stress hormones.

For example, mono or semi mono diets like the rice or potato diet are so effective that they have cured a host of incurable diseases and in addition, the individuals lost weight no matter how much rice or potatoes they consumed. You have to avoid certain foods when on this diet. I have tested both the rice and the potato diet and then did lab work to and found that almost every marker of inflammation was severely reduced.

Athletes generally fare horribly in the later years. Marathon runners hardly ever have long lives and the stress they produce on their bodies from doing those long runs in the long run (no pun intended) overwhelm their system. In general, the body is not supposed to be overly stressed. Excessive exercise is an unnatural state as is fasting. Fasting is not a natural condition and is only done when one has no option. A low inflammatory diet can produce the same if not better results. All one has to do is modulate one’s stressor hormones. Keep inflammatory markers such as CRP, Homocysteine, aldosterone, erythrocyte sedimentation rate (ESR), and procalcitonin (PCT), etc, under control or at low levels.

High homocysteine levels promote higher blood levels of arachidonic acid and prostaglandin E 2 (PGE 2), which are chemicals that your body uses to promote inflammation.

Aldosterone
Aldosterone is a mineralocorticoid hormone that controls body fluid and electrolyte balance. Excess aldosterone is associated with cardiovascular and metabolic diseases. Inflammation plays a critical role on vascular damage promoted by aldosterone and aggravates vascular abnormalities, including endothelial dysfunction, vascular remodeling, fibrosis and oxidative stress, and other manifestations of end-organ damage that are associated with hypertension, other forms of cardiovascular disease, and diabetes mellitus and the metabolic syndrome. https://pubmed.ncbi.nlm.nih.gov/32820797/

Other inflammation markers and there are many

• Ferritin levels: Low iron levels are associated with better health as Iron promotes bacterial growth. I keep this under control by donating blood as much as I can.
  
  Lactate Dehydrogenase (LDH). High levels are associated with inflammation
  
  Neutrophil-Lymphocyte Ratio. High levels of Neutrophils are associated with inflammation. The ideal ratio is in the 1.2 to roughly 1.8 ranges.
  
  Liver enzymes
  Alkaline phosphate. Elevated levels can be a good indicator of inflammation. Anything above 95 could be a sign of inflammation. In general elevated liver enzymes have been associated with cardiometabolic problems https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486915/
  
  ALT and AST both should be in the 10 to 26 IU/L ranges. Elevated levels are usually indicative of inflammation.
  
  GCT: elevated levels could be a sign of liver disease and or inflammation. Normal range 10 to 26IU/L. Levels lower than 10 are usually associated with a B6 deficiency.
  Another stressor hormone is prolactin and I try to keep this under control by taking naps in the day with a red lamp on and by consuming thyroid supplements (low dose) and eating thyroid friendly foods

.

Some things I do to keep inflammation low

I don’t mix too many foods. For example, I generally don’t eat too much meat as it increases inflammation. I am not a vegan. I do like meat but I consume it in moderation (generally) and I try to consume some gelatin with it, to counter the inflammatory effects. For example, my main meal could be potatoes and pork or potatoes and lamb. With that, I will have some salad (no leaves and leaves irritate the gut. My salad is usually tomatoes, cucumbers, some parsley, olive oil, fresh lemon or fresh orange juice on top, every now and then will add Feta Cheese). And that’s it. For dessert, I might have ice cream or chocolate lava cake as long as it contains no wheat. I eat a lot of fruits and I generally have them before the meal unless it's papaya or pineapple as they contain digestive enzymes.

I consume no wheat products at all.
I eat a large number of eggs. It started off as a bet with a doctor 10 years ago when I told him cholesterol was not a big deal as most of its produced by the body. I consume a minimum of 14 eggs per week but the normal range is usually 21. However, I will only eat free-range eggs. 10 years later and I am still fine and the doctor lost the bet.

When it comes to milk, I try to consume raw milk whenever the opportunity presents itself but in the absence of that I will only consume grass-fed mill. I don’t care about the organic factor, if it's not grass fed organic means nothing. The same applies to meat, grass-fed meat, as grain-fed organic meat is nothing but glorified rubbish.
I consume no wheat or wheat-based products at all 99% of the time. I will make at most 12 exceptions per year, but for the past 4 years, I have not even come close to using 6 of those exceptions.

I won’t buy any product if it has an ingredient that I can’t pronounce or if it has too many ingredients. For example, Ice cream. I want Milk, cream and maybe the flavouring they are using for the ice cream anything more than that I won’t eat it or purchase it. If I were to eat bread, I would only consume bread that had the following ingredients, flour, salt, possibly yeast and butter. Anything more and it would be dumped.

I also consume very little corn; I find that maize is better but even then I won’t consume too much of it. I eat no cereal whatsoever. If I drink sodas, they have to have sugar. I won’t touch anything with corn syrup in it. I also keep my starch consumption low, the exception being potatoes because it’s a unique veggie, with lots of minerals and also contains Protein.
I consume a lot of fruits, chocolate with no lecithin in it, lots of coffee (4 to 6 cups a day but before 5 pm),

There are a host of other things I do. I will mention them randomly here

I consume aspirin quite often (in the range of 500 to 1gram at a time) it is an antiviral agent but more importantly, it is an extremely effective agent against inflammation and its pro-thyroid. I will take this with VITK 5mg every 2 days or so.

I take consume ATP tablets or take ATP injections every now and then

Right now I am trying a protocol of Vit C and Alpha lipoic acid intravenous shots. I will see how it goes for 10 days then if all is well, I will do it for 30 days

Every few years I take shots of Cerebrolysin and solcocersol (roughly 1 months worth of treatment)

some random info on Cererbrolysin

Cerebrolysin is purported to be a nootropic, a “smart drug” that can improve cognitive function. It is a mixture of amino acids and proteins derived from pig brains, including:
• Brain-derived neurotrophic factor (BDNF) [1]
• Glial cell line-derived neurotrophic factor (GDNF) [1]
• Nerve growth factor (NGF) [1]
• Ciliary neurotrophic factor (CNTF) [1]

These proteins are also found naturally in the human brain, where they play an important role in brain cell development and repair [2].
Cerebrolysin is not approved for medical use in the United States. However, this drug is sometimes used in a number of European and Asian countries for the treatment of stroke, traumatic brain injury, and dementia [3, 4].
https://selfhacked.com/blog/cerebrolysin-effects/

https://pubmed.ncbi.nlm.nih.gov/19848437/

Some info on Solcoseryl
Pharmacological Properties

The Solcoseryl drug is deproteined hemo-dialysate containing a wide range of low-molecular components of cell mass and blood serum of dairy calves with a molecular weight of 5,000 D (glycoproteins, nucleosides and nucleotides, oligo-peptides, amino acids).
It was established that Solcoseryl has the following properties:
• Solcoseryl improves the transport of oxygen and glucose to the cells in hypoxic conditions;
• It increases intracellular synthesis of ATP and increases the proportion of aerobic glycolysis and oxidative phosphorylation;
• Solcoseryl activates regenerative and reparative processes in the tissue;
• It stimulates fibroblast proliferation and collagen synthesis vessel walls.
Other info on Solcoseryl
https://pubmed.ncbi.nlm.nih.gov/12755779/
https://pubmed.ncbi.nlm.nih.gov/1932775/
https://pubmed.ncbi.nlm.nih.gov/3110040/
https://pubmed.ncbi.nlm.nih.gov/943723/

I also consume no PUFA based oils, that means zero fish oil or anything to do with Omega 6 and all seed-based oils except for coconut, palm and grass-fed better or lard that is obtained from grass-fed animals

Lastly Methylene blue plays an important role in my life. I consume it almost every day and then take a break of roughly 1 week every 30 to 40 days.

Okay that's enough i could probably write a book on the things i have done and continue to do

[stefk]

Well, Sol, its impressive, you are a real bio engineer of your body.

.............................................



This is an easier asana accessible for everybody, and the benefits are the sames. Its Servangasana, the queen of the asanas

Benefits

Calms the brain and helps relieve stress and mild depression
Stimulates the thyroid and prostate glands and abdominal organs
Stretches the shoulders and neck
Tones the legs and buttocks
Improves digestion
Helps relieve the symptoms of menopause
Reduces fatigue and alleviates insomnia
Therapeutic for asthma, infertility, and sinusitis

[SOL]

Well, Sol, its impressive, you are a real bio engineer of your body.

Thank you, it took years of research but I feel it was worth it. Health plays a big role in my life and one of the first places to start off on the road to good health is to lose any extra poundage.

I would say you are also very knowledgeable especially when it comes to many ancient practices, which I also believe hold great value if utilised properly.

[stefk]

Yes Sol, health should play an important role for everybody. But its not the case. When I see my colleagues, my neighbours, and also some members of my family, their health is not their priority. I consider my health as a capital I received from my parents, or from God, or from the nature, or from my grand grand..... fathers and mothers. Maintaining and improving this capital, is the best investment for a TI.

To lose the extra pounds we have too much, the best for me is to become more insuline sensitive, its my number one priority. There are two essential hormones in our bodies we can ourselves manipulate, insuline and testosterone. The young men have 40% less testo in the blood than 50 years ago. Therefore there is a big belly pandemy in western countries. Big belly means white fat, this fat is toxic for the heart, stomach and liver. The priority number two would be to increase testosterone levels.

[Yodean]

To lose the extra pounds we have too much, the best for me is to become more insuline sensitive, its my number one priority. There are two essential hormones in our bodies we can ourselves manipulate, insuline and testosterone. The young men have 40% less testo in the blood than 50 years ago. Therefore there is a big belly pandemy in western countries. Big belly means white fat, this fat is toxic for the heart, stomach and liver. The priority number two would be to increase testosterone levels.

Yeh, this is the true pandemic, the "Big Belly" Pandemic, much more dangerous than cv19!

I am 48-years-old, before lockdowns, had about 11% to 13% body fat, very strong and fit, but gained some weight during lockdowns, now lost a bit so back to about 13% to 15%. Trying to get back down to that 11% to 14% range - gotta keep the wife satisfied!

Indeed, increasing testosterone and improving insulin sensitivity are really important, and I focus on this too. I would also add trying to increase growth hormone levels (naturally) is also very important - some call growth hormone the true "fountain of youth," or "anti-aging" hormone.

Interestingly, intermittent fasting and appropriate exercise increase all three significantly (testosterone, insulin sensitivity, growth hormone levels). Certainly, too much fasting and exercise will lead to excessively increased cortisol levels, etc., but the right "doses" of exercise and fasting, with appropriate recovery, will not place undue stress on your body.

I cycle between different types of exercises to challenge the body, including Russian kettlebell exercises, Indian club training, bodyweight resistance training, some jogging, kayaking during the summer, ping pong, etc.

My five kettlebells are among the best investments I ever made - I got them over ten years ago, and they last forever. They will be here while I am alive, and I expect them to last for decades after I am gone. Pretty much indestructible.

Those Russians really know what they're talking when it comes to physical training.

[Yodean]

Its Servangasana, the queen of the asanas

@stefk: Is this the Prince of the Asanas?

[ultramartian]

Well, Sol, its impressive, you are a real bio engineer of your body.

.............................................



This is an easier asana accessible for everybody, and the benefits are the sames. Its Servangasana, the queen of the asanas

Benefits

Calms the brain and helps relieve stress and mild depression
Stimulates the thyroid and prostate glands and abdominal organs
Stretches the shoulders and neck
Tones the legs and buttocks
Improves digestion
Helps relieve the symptoms of menopause
Reduces fatigue and alleviates insomnia
Therapeutic for asthma, infertility, and sinusitis

How about the use of inversion table to achieve the same goals above? I have been using inversion table at least twice a day for more than a year now to ease my herniated pine in the lower back. It has certainly helped me in my lower back but I am not aware of the benefits mentioned in the asana pose above. Maybe it did these benefits to me unknowingly.

[stefk]

@ultramartian.

https://yogauonline.com/yoga-anatomy/up ... -and-heart

Yes you will benefit of the inverse pose. Your heart will work easier, your veins circulation will flow more easily, your brain will be more oxyginated, your diaphragm will strengten, a lot of positive things. But with the table, you will not be limited in the time, the servangasana is more tiring, so naturally the body feels the time limit by himself, it will not be the case with the table. so, be careful and go progressively.

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@Yodean; Yes it could be the prince, its a semi inverted pose, with a fantastic flexion of the spine. But the problem with chakrasana, you can not hold it for a long time. Why did the ancients call the two inverted poses king and queen ? because the benefits of these asanas are so great, you can skip all the other asanas.

With this file, I returned to my yoga books, and I reopened my yoga pradipika, its in fact an instruction manual for the sect of natha yogins. And for the natha yogins, the inverted poses are not asanas, its a mudra, its more powerful. And I read page 193, its in french, ET CHAQUE JOUR, AUGMENTER NE SERAIT CE QUE TRES PEU LA DUREE, AU BOUT DE SIX MOIS LES RIDES ET LES CHEVEUX GRIS ONT DISPARU; CELUI QUI PRATIQUE CECI PENDANT TOIS HEURES CHAQUE JOUR EST VAINQUEUR DE LA MORT. ""go very progressively, the one who practices it during three hours everyday is vanquisher of death."" it will say that you become stronger than death and you postpone the day of your death.....,

But the asanas are only a little part of yoga. There are mudras, bandhas, and very important the pranayama. for me the most effective pranayama is uddiyana bandha.

In the yoga pradipika, he presents only ten asanas, one of these is mayurasana, very interesting.


The Hatha Yoga Pradipika (HYP), chapter 1, verses 30 – 31, tells us:
Hold the Earth with both hands. Place the sides of the navel on the elbows. Rise high above the ground like a stick. This is Mayurasana.
The Sri [holy] Mayurasana overcomes defects and quickly destroys all diseases—enlargement of the spleen, enlargement of the abdomen, and so on. It stimulates the stomach’s fire, incinerates all bad food, and makes the deadly Kalakuta poison digestible.



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Good books to learn the science of yoga:

yoga pradipika

yoga dipika, BKS Iyengar

yoga, a gem for women, Gita S Iyengar

[Yodean]

Yes it could be the prince, its a semi inverted pose, with a fantastic flexion of the spine. But the problem with chakrasana, you can not hold it for a long time. Why did the ancients call the two inverted poses king and queen ? because the benefits of these asanas are so great, you can skip all the other asanas.

ET CHAQUE JOUR, AUGMENTER NE SERAIT CE QUE TRES PEU LA DUREE, AU BOUT DE SIX MOIS LES RIDES ET LES CHEVEUX GRIS ONT DISPARU; CELUI QUI PRATIQUE CECI PENDANT TOIS HEURES CHAQUE JOUR EST VAINQUEUR DE LA MORT. ""go very progressively, the one who practices it during three hours everyday is vanquisher of death."" it will say that you become stronger than death and you postpone the day of your death.....,

Thanks for all this information. I am not currently planning on becoming a yogi, and in a perverse way I look forward to the extinquishing of "my" body-mind shell, as I am mildly curious as to what lies beyond the physical plane of existence.

In any case, I tend to believe our time of death is preordained by Higher Forces, so although I enjoy being and staying healthy, ultimately for me it is more about staying highly functional for as long as possible, as well as having as much fun as possible, rather than slowing the aging process down per se.

I do like those three postures/exercises you discussed, and will rotate them into my training routine. I can already do the "Prince of the Asanas" (that's me in the photo from the previous post, taken this morning in the local park) fairly comfortably, as well as the "Queen of the Asanas."

The "King of the Asanas" I have only been partially able to do, and it looks like it will take some time to develop competency in this posture.

Are you able to do all three, at 61-years of age?

[SOL]

Yes Sol, health should play an important role for everybody. But its not the case. When I see my colleagues, my neighbours, and also some members of my family, their health is not their priority. I consider my health as a capital I received from my parents, or from God, or from the nature, or from my grand grand..... fathers and mothers. Maintaining and improving this capital, is the best investment for a TI.

To lose the extra pounds we have too much, the best for me is to become more insuline sensitive, its my number one priority. There are two essential hormones in our bodies we can ourselves manipulate, insuline and testosterone. The young men have 40% less testo in the blood than 50 years ago. Therefore there is a big belly pandemy in western countries. Big belly means white fat, this fat is toxic for the heart, stomach and liver. The priority number two would be to increase testosterone levels.

Join the club. I see this with friends, family and many of my associates. Thankfully more members of my family are focusing on health. However, I tell those that are not in shape that even if they have a million or two or more than they are poor and that I would never exchange positions with them. In 2013 when I had a hard time tying my shoelaces by simply bending over I decided it was time to change and now when I look at my pictures I look better than I did back in 2013. I just let myself go out of shape for roughly 15 months due to overworking but that was long enough. But I was never obese but I did develop a belly that I did not want. it feels good to lose extra poundage, it's like getting a new lease on life. Removing wheat and corn syrup from my diet (I would not read all the labels in detail as I do so now) made losing the extra pounds quite easy.

[AstuteShift]

Weight loss is a paradox unto itself

Easy to do yet many can’t

The real reason is due to the tortoise vs the hare scenario

Many want quick results and quit early