Life extension theraphies and more

[harryg]

Why do married men die before their wives?

What about if a trans-man were married to a trans-woman?

Who lives longer?

Hmmmmmmmm ...

I should imagine that in that situation each would wish to die before the other.

[Tobeornot]

Why do married men die before their wives?

What about if a trans-man were married to a trans-woman?

Who lives longer?

Hmmmmmmmm ...

I should imagine that in that situation each would wish to die before the other.

Harry you are a Gem. I am not British but I remember hearing that phrase in a movie I watched sometime ago. Man you made my day lol

[Budge]

What about if a trans-man were married to a trans-woman?

Who lives longer?

Hmmmmmmmm ...

I should imagine that in that situation each would wish to die before the other.

Harry you are a Gem. I am not British but I remember hearing that phrase in a movie I watched sometime ago. Man you made my day lol

Back in the day, the term "tranny" was used for the radio (transistor radio). These days the confusion could cause a world of woe for us old fogies. But, on the other hand, who said satire was dead? Citizens for Sanity are employing billboards to go after the woke/progressives ("proke" maybe or "wo..."!! maybe not):

In Atlanta, GA: “Thank you, Senator Warnock, for voting to keep violent criminals out of jail. Gang members need to earn a living too.”

“Thank you, Senator Warnock, for voting to keep violent predators out of jail. Unmasked toddlers are the real criminals.”

In Las Vegas, NV: “Thank you, Catherine Cortez Masto, for voting to keep our border open. Drug cartels need all the help they can get.”

In Phoenix, AZ: “Thank you, Mark Kelly, for voting to keep our borders open. The drugs aren’t going to smuggle themselves.”

In Epping, NH: “Thank you, Senator Hassan, for voting to keep our border open. Drug cartels need all the help they can get.”

In Philadelphia: “Thank you, John Fetterman, for fighting to keep violent criminals out of jail. Gang members need to earn a living too.”

In Miami, FL: Thank you, Val Demings, for fighting to keep violent criminals out of jail.”

The organization goes on to attack the IRS: “If you do not like being audited then you’re the problem.”

“Too much freedom is a bad thing. Get your IRS audit today.”

https://www.armstrongeconomics.com/inte ... or-sanity/

[scott]

Back in the day, the term "tranny" was used for the radio (transistor radio). These days the confusion could cause a world of woe for us old fogies. But, on the other hand, who said satire was dead? Citizens for Sanity are employing billboards to go after the woke/progressives ("proke" maybe or "wo..."!! maybe not):

Girls volleyball team banned from locker room after trans teammate complaints: Report
https://www.msn.com/en-us/sports/nba/gi ... r-AA12yuEa

[Yodean]

Girls volleyball team banned from locker room after trans teammate complaints: Report
https://www.msn.com/en-us/sports/nba/gi ... r-AA12yuEa

Similar vein, quite funny:

https://youtu.be/g6F3lCUTGEA

[Budge]

Back in the day, the term "tranny" was used for the radio (transistor radio). These days the confusion could cause a world of woe for us old fogies. But, on the other hand, who said satire was dead? Citizens for Sanity are employing billboards to go after the woke/progressives ("proke" maybe or "wo..."!! maybe not):

Girls volleyball team banned from locker room after trans teammate complaints: Report
https://www.msn.com/en-us/sports/nba/gi ... r-AA12yuEa

Interesting that the girls are subject to an investigation but not the transistor radio who allegedly made an improper remark.

[SOL]

https://www.youtube.com/watch?v=fX9P1xuIJGg

[bpcw]

Well the PTB aren't going to like that are they, unless they can fool enough people in taking a drug that will do the reverse and speed up the aging process!

[SOL]

A breakthrough offers a potential target for treating heart failure patients.
An anti-aging gene found in centenarians has been shown to reverse the heart’s biological age by 10 years. This groundbreaking discovery, published in the journal Cardiovascular Research and led by scientists from the University of Bristol and MultiMedica Group in Italy, offers a potential target for heart failure patients.

Individuals who carry healthy mutant genes, commonly found in populations known for exceptional longevity such as the “blue zones,” often live to 100 years or more and remain in good health. These carriers are also less susceptible to cardiovascular complications. Scientists funded by the British Heart Foundation believe the gene helps keep their hearts youthful by guarding against diseases related to aging, such as heart failure.

In this new study, researchers demonstrate that one of these healthy mutant genes, previously proved particularly frequent in centenarians, can protect cells collected from patients with heart failure requiring cardiac transplantation.

The Bristol team, led by Professor Paolo Madeddu, has found that a single administration of the mutant anti-aging gene halted the decay of heart function in middle-aged mice. Even more remarkably, when given to elderly mice, whose hearts exhibit the same alterations observed in elderly patients, the gene rewound the heart’s biological clock age by the human equivalent of more than ten years.

Professor Madeddu, Professor of Experimental Cardiovascular Medicine from Bristol Heart Institute at the University of Bristol and one of the study’s authors, explained: “The heart and blood vessel function is put at stake as we age. However, the rate at which these harmful changes occur is different among people. Smoking, alcohol, and sedentary life make the aging clock faster. Whereas eating well and exercising delay the heart’s aging clock.

“In addition, having good genes inherited from parents can help to stay young and healthy. Genes are sequences of letters that encode proteins. By chance, some of these letters can mutate. Most of these mutations are insignificant; in a few cases, however, the mutation can make the gene function worse or better, like for the mutant anti-aging gene we have studied here on human cells and older mice.”

The three-year study was also performed in test tube human cardiac cells in Italy. Researchers from the MultiMedica Group in Milan led by Professor Annibale Puca, administered the gene in heart cells from elderly patients with severe heart problems, including transplantation, and then compared their function with those of healthy individuals.

Monica Cattaneo, a researcher of the MultiMedica Group in Milan, Italy, and first author of the work said: “The cells of the elderly patients, in particular those that support the construction of new blood vessels, called ‘pericytes’, were found to be less performing and more aged. By adding the longevity gene/protein to the test tube, we observed a process of cardiac rejuvenation: the cardiac cells of elderly heart failure patients have resumed functioning properly, proving to be more efficient in building new blood vessels.”

Centenarians pass their healthy genes to their offspring. The study demonstrates for the first time that a healthy gene found in centenarians could be transferred to unrelated people to protect their hearts. Other mutations might be found in the future with similar or even superior curative potential than the one investigated by this research. Professor Madeddu and Professor Annibale Puca of the MultiMedica Group in Milan believe this study may fuel a new wave of treatments inspired by the genetics of centenarians.

Professor Madeddu added: “Our findings confirm the healthy mutant gene can reverse the decline of heart performance in older people. We are now interested in determining if giving the protein instead of the gene can also work. Gene therapy is widely used to treat diseases caused by bad genes. However, a treatment based on a protein is safer and more viable than gene therapy.

“We have received funding from the Medical Research Council to test healthy gene therapy in Progeria. This genetic disease, also known as Hutchinson-Gilford syndrome, causes early aging damage to children’s hearts and blood vessels. We have also been funded by the British Heart Foundation and Diabetes UK to test the protein in older and diabetic mice, respectively.”

Annibale Puca, Head of the laboratory at the IRCCS MultiMedica and Professor at the University of Salerno, added: “Gene therapy with the healthy gene in mouse models of disease has already been shown to prevent the onset of atherosclerosis, vascular aging, and diabetic complications, and to rejuvenate the immune system.

“We have a new confirmation and enlargement of the therapeutic potential of the gene/protein. We hope to test its effectiveness soon in clinical trials on patients with heart failure.”

[MarkD]

That is interesting. Count me in.

[scott]

That is interesting. Count me in.

Want to live forever? I'm expecting something else.





https://www.youtube.com/watch?v=qN5zw04WxCc

[stefk]

https://www.researchgate.net/publicatio ... armacology

The pycnogenol, from the french maritime pine. This supplement seems really too good to be true. But when you read or see dozens of trials that all show wonderful positive effects, it seems the positive effects are real.

...........................................................................


https://www.livestrong.com/article/4034 ... d-for-you/

This simple food, sardines in tin can, is for me the best food you can put on your table, minimum one time a week.

Choose them in olive oil, I prepare them in rillettes, delicious for the taste, and healthy for the heart.....

[Cinnamon]

Well these individuals look like they would love to dine on some sardines

https://youtu.be/EmX2EP9iKwQ

[Yodean]

Largely ignored and pushed aside in years past, poor mental health has emerged in recent decades as a modern problem of epidemic proportions.

Poor mental health is as nuanced as it is difficult to treat, but the research team believes exercise should most definitely be a mainstay approach for managing depression.

Why? The study finds regular physical activity was 1.5 times more effective than either counseling or the leading medications.

In what researchers are calling the most comprehensive review of this topic thus far, the study included 97 reviews, 1039 trials, and 128,119 participants.

Ultimately, study authors report exercise is extremely beneficial for improving symptoms linked to depression, anxiety, and distress.

https://bjsm.bmj.com/content/early/2023 ... ystem-main

https://www.naturalblaze.com/2023/02/ex ... study.html

*****

[chippermon]

Largely ignored and pushed aside in years past, poor mental health has emerged in recent decades as a modern problem of epidemic proportions.

Poor mental health is as nuanced as it is difficult to treat, but the research team believes exercise should most definitely be a mainstay approach for managing depression.

Why? The study finds regular physical activity was 1.5 times more effective than either counseling or the leading medications.

In what researchers are calling the most comprehensive review of this topic thus far, the study included 97 reviews, 1039 trials, and 128,119 participants.

Ultimately, study authors report exercise is extremely beneficial for improving symptoms linked to depression, anxiety, and distress.

https://bjsm.bmj.com/content/early/2023 ... ystem-main

https://www.naturalblaze.com/2023/02/ex ... study.html

*****

Was it largely ignored? Was it pushed aside? Or did we create a society that would gravitate to poor mental health and depression. A society that would rather sit in the basement playing video games and watching the idiot box instead of getting out and doing stuff that would be considered exercise. You know, fun stuff like snowboarding, skateboarding, hockey, basketball, tennis or just walking for christ's sake. ie. moving around. When we were kids we couldn't wait to get outside and mess around. Not that way anymore. That's the reason it's emerged in recent decades.

Isn't this the reason we can't find people to fill vacant jobs, especially jobs that require physical effort, or get people to do anything productive at work?