Methlyene blue

[scott]

Thanks SOL, not sure, too soon to tell if its MB, might just seem that way. I'll work it out.

[Yodean]

Thanks SOL, not sure, too soon to tell if its MB, might just seem that way. I'll work it out.

I've ordered some MB to try and it's set to arrive soon, so am not speaking from direct experience. Will delve into the research a bit more when it arrives and the experimentation begins.

Sol mentioned that MB kills pathogens ... bacteria, viruses, etc.

Emerging, robust research is showing that a balanced, healthy gut microbiome is quite important for overall health in countless ways. Basically, the idea is you want to have the right proportions of different types of healthy bacteria living in harmony in your G.I. system (and elsewhere, as well, like on your skin).

Ties in a bit with the Hygiene Hypothesis - prolly worth spending half an hour or so reading up a bit on this with a quick search.

So if MB does indeed kill bacteria, and assuming it reaches the lower parts of your small intestine and colon (large intestine), the MB could be affecting the integrity of your gut microbiome by upsetting the balance of the different types of bacteria living there. This could lead to changes in BMs, in both directions ... either temporarily or more permanently.

[scott]

Thanks SOL, not sure, too soon to tell if its MB, might just seem that way. I'll work it out.

I've ordered some MB to try and it's set to arrive soon, so am not speaking from direct experience. Will delve into the research a bit more when it arrives and the experimentation begins.

Sol mentioned that MB kills pathogens ... bacteria, viruses, etc.

Emerging, robust research is showing that a balanced, healthy gut microbiome is quite important for overall health in countless ways. Basically, the idea is you want to have the right proportions of different types of healthy bacteria living in harmony in your G.I. system (and elsewhere, as well, like on your skin).

Ties in a bit with the Hygiene Hypothesis - prolly worth spending half an hour or so reading up a bit on this with a quick search.

So if MB does indeed kill bacteria, and assuming it reaches the lower parts of your small intestine and colon (large intestine), the MB could be affecting the integrity of your gut microbiome by upsetting the balance of the different types of bacteria living there. This could lead to changes in BMs, in both directions ... either temporarily or more permanently.

That was my initial thinking, G.I. flora. Also could be some extra ingredients in the fishtank MB I'm trying.
As an aside, but along the same lines, we get raw milk every sunday and I tried some couple of weeks ago before pasteurizing. Good stuff for my BMs, might make it a habit.

[SOL]

Thanks SOL, not sure, too soon to tell if its MB, might just seem that way. I'll work it out.

I've ordered some MB to try and it's set to arrive soon, so am not speaking from direct experience. Will delve into the research a bit more when it arrives and the experimentation begins.

Sol mentioned that MB kills pathogens ... bacteria, viruses, etc.

Emerging, robust research is showing that a balanced, healthy gut microbiome is quite important for overall health in countless ways. Basically, the idea is you want to have the right proportions of different types of healthy bacteria living in harmony in your G.I. system (and elsewhere, as well, like on your skin).

Ties in a bit with the Hygiene Hypothesis - prolly worth spending half an hour or so reading up a bit on this with a quick search.

So if MB does indeed kill bacteria, and assuming it reaches the lower parts of your small intestine and colon (large intestine), the MB could be affecting the integrity of your gut microbiome by upsetting the balance of the different types of bacteria living there. This could lead to changes in BMs, in both directions ... either temporarily or more permanently.

It supposedly acts on pathogenic agents, in this case bad bacteria would be targeted and good bacteria would be left alone

Here is a huge study that someone with your background could summarize probably in one paragraph

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673545/

[harryg]

Emerging, robust research is showing that a balanced, healthy gut microbiome is quite important for overall health in countless ways. Basically, the idea is you want to have the right proportions of different types of healthy bacteria living in harmony in your G.I. system (and elsewhere, as well, like on your skin).

Ties in a bit with the Hygiene Hypothesis - prolly worth spending half an hour or so reading up a bit on this with a quick search.

Indeed, Alien N, I looked into this quite a lot in the past as had some recurrent digestive issues.

A French book named the stomach/digestive tract the "Second Brain". Not that I need a second brain, the first one is annoying enough.

I also received a tip that I chose not to follow - eating someone else's ***. You could get it in a sanitised version, but still...

I prefer the live yoghourt type of route. Sauerkraut is supposedly good, too.

[SOL]

Emerging, robust research is showing that a balanced, healthy gut microbiome is quite important for overall health in countless ways. Basically, the idea is you want to have the right proportions of different types of healthy bacteria living in harmony in your G.I. system (and elsewhere, as well, like on your skin).

Ties in a bit with the Hygiene Hypothesis - prolly worth spending half an hour or so reading up a bit on this with a quick search.

Indeed, Alien N, I looked into this quite a lot in the past as had some recurrent digestive issues.

A French book named the stomach/digestive tract the "Second Brain". Not that I need a second brain, the first one is annoying enough.

I also received a tip that I chose not to follow - eating someone else's ***. You could get it in a sanitised version, but still...

I prefer the live yoghourt type of route. Sauerkraut is supposedly good, too.

In Russia or the EAST I forget where now but they refer to the intestine as the second lung which I believe is more apt of a name but I digress. If you want to boost the good bacteria one decent alternative is to take enterically coated probiotics, this way they all make it to the intestine, supposedly a large percentage die in transit due to the acid in the stomach

This product could be quite useful
https://www.lifeextension.com/vitamins- ... technology

[Yodean]

Here is a huge study that someone with your background could summarize probably in one paragraph

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673545/

Overall, pretty decent study, in terms of accomplishing what it sets out to do.

My 2c:

-it's an animal study (mice), so ultimately, no matter the quality in terms of its size or structure, it falls in the "hypothesis-generating" category of studies: i.e. it brings forth potentially interesting ideas for further study in formal human studies, as opposed to "hypothesis-proving," i.e. proving something is likely true or not;

-human biological systems are complex with lots of inter-individual variation, and as a general rule, animal studies are good starting points, but often results found in animal studies could not be duplicated in subsequent human studies; side effect profile, both short- and long-term, are also often quite different, between animal and human studies studying the same treatment;

-the animal study under discussion shows beneficial cognitive effects of MB on really young, healthy mice in the short-term; we do not know about long-term effects - e.g. whether there is some type of reversion back to the mean in terms of cognitive abilities, or whether new side effects emerge over a longer period of time, or whether the beneficial effects extend to older mice, especially those with pre-existing co-morbidities;

-interestingly, the beneficial cognitive effects of MB on mice in the study disappeared with a higher dose of MB, and the higher dose of MB appeared to show some potentially harmful effects (dysbiosis) on the gut microbiome of the mice who received the higher doses; this could be construed as a "red flag" of sorts, as one generally wants to demonstrate a "dose-response" relationship when evaluating the potential positive effects of a treatment (e.g. more benefits with higher doses);

-more likely, this lack of a "dose-response" relationship often indicates that the therapeutic range (the range of doses at which MB is beneficial) is quite narrow, meaning that outside of a small range of doses for a given individual, MB is potentially harmful or may show little benefit;

-on balance, when results of the current study are taken in conjunction with those of other studies on MB (the few others at which I have had a cursory look thus far), MB does appear to hold some promise in improving certain cognitive parameters in humans - but results will likely vary among individuals, as well as side effects, and the optimum dose, as well as duration (e.g. how often to take - daily, or a few times a week, or several times a day, etc., and for how long - forever? or a few months at a time, with "drug holidays" when you cycle off MB for weeks or a few days, etc.) will likely be different for each individual;

-like with most supplements, extensive individual experimentation is required;

[Yodean]

Indeed, Alien N, I looked into this quite a lot in the past as had some recurrent digestive issues.

A French book named the stomach/digestive tract the "Second Brain". Not that I need a second brain, the first one is annoying enough.

I also received a tip that I chose not to follow - eating someone else's ***. You could get it in a sanitised version, but still...

I prefer the live yoghourt type of route. Sauerkraut is supposedly good, too.

The idea that the G.I. tract (GIT) is a 2nd brain is quite a good one, and is even gaining traction among mainstream medicine at a rapid pace. In fact, one could even make a strong case that the GIT is actually the 1st brain, i.e. primary, in many ways, in terms of how it affects an individual's decision-making and moods, etc. But that is a broad topic for another time, perhaps. As a small example, >80% of the serotonin (one of the "happy" neuro-chemicals) is created by your GIT, broadly speaking, from what I remember. In many ways, we are what we eat (or how we fast).

In terms of the Hygiene Hypothesis, it is not quite necessary to consume another's feces to be healthy.

For example, you have a dog - no matter how often you wash your dog, your dog, assuming it is a normal dog which runs around outside and at least occasionally licks various objects, including other canine anuses, would pick up a diverse microbiome to which you would be exposed. In general, this is actually quite healthy for you (and your dog, of course), as it serves to prime your immune system to be versatile and used to dealing with a variety of organisms. Also, exposing yourself to a diverse range of organisms generally prevents any one single organism from gaining dominance in any particular region or sector of your body, and thereby cause problems for you.

Scattered, small studies have consistently demonstrated that people with dogs are generally healthier than those without, when other factors are accounted for. Some of this may be attributed to the emotional aspects of owning a pet - i.e. your dog is going to give you love and attention regardless of your performance in the stock markets - as well as the dog forcing the human owner to engage in more exercise outdoors through walks with the pet in question.

Other studies have shown that children who grow up on farms - i.e. kinda dirty, around other animals - tend to be healthier than city kids, in terms of lower rates of diseases like asthma and having significant allergies. Once again, prolly for multiple reasons, but I suspect the Hygiene Hypothesis also holds some sway here.

And then there are those studies that on balance, seem to show that people who like socializing in groups - like going to concerts, going out a lot to pubs with friends, praying to an imaginary Deity in a church with others, etc. - also tend to be healthier, on average, than those who stay home, alone. Of course, lots of possible reasons for this, as well as selection bias - people who are sick are less able to go out as often, for one - but one theory you don't hear a lot about is that when one goes out a lot and interacts with a lot of individuals, one is exposing oneself to a wide range of organisms (through hugging, shaking hands, breathing each others' air, spitting a bit on each other when conversing in close proximity, etc.), which is likely good for you, healthwise.

So maintaining a good, diverse microbiome (in the GIT as well as elsewhere) does not necessarily have to involve a lot of work.

Examples of some easy steps:

-have a dog/cat;
-go camping;
-use simple soaps (not the antibacterial ones);
-avoid antibiotics unless absolutely necessary - force your own immune system to get stronger by dealing with the problem;
-work in your garden or soil with bare hands and bare feet, when possible (additional benefits of earthing/grounding);
-play some games with unwashed children;
-eat some street food;
-occasionally engage in mildly dirty sex with your partner(s);

[scott]

I've noticed dogs and cats eat some grass, when (presumably, they didn't tell me) they have a tummy ache.

[SOL]

The idea that the G.I. tract (GIT) is a 2nd brain is quite a good one, and is even gaining traction among mainstream medicine at a rapid pace. In fact, one could even make a strong case that the GIT is actually the 1st brain, i.e. primary, in many ways, in terms of how it affects an individual's decision-making and moods, etc. But that is a broad topic for another time, perhaps. As a small example, >80% of the serotonin (one of the "happy" neuro-chemicals) is created by your GIT, broadly speaking, from what I remember. In many ways, we are what we eat (or how we fast).

In terms of the Hygiene Hypothesis, it is not quite necessary to consume another's feces to be healthy.

For example, you have a dog - no matter how often you wash your dog, your dog, assuming it is a normal dog which runs around outside and at least occasionally licks various objects, including other canine anuses, would pick up a diverse microbiome to which you would be exposed. In general, this is actually quite healthy for you (and your dog, of course), as it serves to prime your immune system to be versatile and used to dealing with a variety of organisms. Also, exposing yourself to a diverse range of organisms generally prevents any one single organism from gaining dominance in any particular region or sector of your body, and thereby cause problems for you.

Scattered, small studies have consistently demonstrated that people with dogs are generally healthier than those without, when other factors are accounted for. Some of this may be attributed to the emotional aspects of owning a pet - i.e. your dog is going to give you love and attention regardless of your performance in the stock markets - as well as the dog forcing the human owner to engage in more exercise outdoors through walks with the pet in question.

Other studies have shown that children who grow up on farms - i.e. kinda dirty, around other animals - tend to be healthier than city kids, in terms of lower rates of diseases like asthma and having significant allergies. Once again, prolly for multiple reasons, but I suspect the Hygiene Hypothesis also holds some sway here.

And then there are those studies that on balance, seem to show that people who like socializing in groups - like going to concerts, going out a lot to pubs with friends, praying to an imaginary Deity in a church with others, etc. - also tend to be healthier, on average, than those who stay home, alone. Of course, lots of possible reasons for this, as well as selection bias - people who are sick are less able to go out as often, for one - but one theory you don't hear a lot about is that when one goes out a lot and interacts with a lot of individuals, one is exposing oneself to a wide range of organisms (through hugging, shaking hands, breathing each others' air, spitting a bit on each other when conversing in close proximity, etc.), which is likely good for you, healthwise.

So maintaining a good, diverse microbiome (in the GIT as well as elsewhere) does not necessarily have to involve a lot of work.

Examples of some easy steps:

-have a dog/cat;
-go camping;
-use simple soaps (not the antibacterial ones);
-avoid antibiotics unless absolutely necessary - force your own immune system to get stronger by dealing with the problem;
-work in your garden or soil with bare hands and bare feet, when possible (additional benefits of earthing/grounding);
-play some games with unwashed children;
-eat some street food;
-occasionally engage in mildly dirty sex with your partner(s);

Lots of good information. I agree getting dirty does help with the immune system. As for those that do take antibiotics, the way to help restore your body back to the norm is to get a mega-dose of probiotics and make sure they are enterically coated so the contents can make it safely to your intestines.

[SOL]

A French book named the stomach/digestive tract the "Second Brain". Not that I need a second brain, the first one is annoying enough.

I also received a tip that I chose not to follow - eating someone else's ***. You could get it in a sanitised version, but still...

I prefer the live yoghourt type of route. Sauerkraut is supposedly good, too.

What could go wrong, you are already in the S**TS and now you are being told to well consume more S**T or have it shot up your anus. I could see where any man of reason would longingly almost lovingly reach for Live Yoghourt

Hopefully you are not at this stage yet

https://www.youtube.com/watch?v=oy7cHLB ... ssiveVoice

[harryg]

I've noticed dogs and cats eat some grass, when (presumably, they didn't tell me) they have a tummy ache.

Yes, very frequent

viewtopic.php?p=10889#p10889

[harryg]

Indeed, Alien N, I looked into this quite a lot in the past as had some recurrent digestive issues.

A French book named the stomach/digestive tract the "Second Brain". Not that I need a second brain, the first one is annoying enough.

I also received a tip that I chose not to follow - eating someone else's ***. You could get it in a sanitised version, but still...

I prefer the live yoghourt type of route. Sauerkraut is supposedly good, too.

The idea that the G.I. tract (GIT) is a 2nd brain is quite a good one, and is even gaining traction among mainstream medicine at a rapid pace. In fact, one could even make a strong case that the GIT is actually the 1st brain, i.e. primary, in many ways, in terms of how it affects an individual's decision-making and moods, etc. But that is a broad topic for another time, perhaps. As a small example, >80% of the serotonin (one of the "happy" neuro-chemicals) is created by your GIT, broadly speaking, from what I remember. In many ways, we are what we eat (or how we fast).

In terms of the Hygiene Hypothesis, it is not quite necessary to consume another's feces to be healthy.

For example, you have a dog - no matter how often you wash your dog, your dog, assuming it is a normal dog which runs around outside and at least occasionally licks various objects, including other canine anuses, would pick up a diverse microbiome to which you would be exposed. In general, this is actually quite healthy for you (and your dog, of course), as it serves to prime your immune system to be versatile and used to dealing with a variety of organisms. Also, exposing yourself to a diverse range of organisms generally prevents any one single organism from gaining dominance in any particular region or sector of your body, and thereby cause problems for you.

Scattered, small studies have consistently demonstrated that people with dogs are generally healthier than those without, when other factors are accounted for. Some of this may be attributed to the emotional aspects of owning a pet - i.e. your dog is going to give you love and attention regardless of your performance in the stock markets - as well as the dog forcing the human owner to engage in more exercise outdoors through walks with the pet in question.

Other studies have shown that children who grow up on farms - i.e. kinda dirty, around other animals - tend to be healthier than city kids, in terms of lower rates of diseases like asthma and having significant allergies. Once again, prolly for multiple reasons, but I suspect the Hygiene Hypothesis also holds some sway here.

And then there are those studies that on balance, seem to show that people who like socializing in groups - like going to concerts, going out a lot to pubs with friends, praying to an imaginary Deity in a church with others, etc. - also tend to be healthier, on average, than those who stay home, alone. Of course, lots of possible reasons for this, as well as selection bias - people who are sick are less able to go out as often, for one - but one theory you don't hear a lot about is that when one goes out a lot and interacts with a lot of individuals, one is exposing oneself to a wide range of organisms (through hugging, shaking hands, breathing each others' air, spitting a bit on each other when conversing in close proximity, etc.), which is likely good for you, healthwise.

So maintaining a good, diverse microbiome (in the GIT as well as elsewhere) does not necessarily have to involve a lot of work.

Examples of some easy steps:

-have a dog/cat;
-go camping;
-use simple soaps (not the antibacterial ones);
-avoid antibiotics unless absolutely necessary - force your own immune system to get stronger by dealing with the problem;
-work in your garden or soil with bare hands and bare feet, when possible (additional benefits of earthing/grounding);
-play some games with unwashed children;
-eat some street food;
-occasionally engage in mildly dirty sex with your partner(s);

Thank you sharing comprehensive info. I agree with most of the above.

Have heard lots of anecdotal stories about children growing up on farms and not suffering from asthma (despite mites, pollens, dust etc). Asthma seems to be out of control if you believe the numbers (12% of UK population).

There was a great wave of utterly cleansing/disinfecting everything, I remember TV programmes where they went into people's houses and measured all the "germs" on their kitchen worktop and so on. The idea was to show how revoltingly dirty and unhealthy it was.

Now I'm off to lick my dog.




Dirty Harry




EDIT: DId I say lick? I meant walk...

[scott]

Thank you sharing comprehensive info. I agree with most of the above.

Have heard lots of anecdotal stories about children growing up on farms and not suffering from asthma (despite mites, pollens, dust etc). Asthma seems to be out of control if you believe the numbers (12% of UK population).

There was a great wave of utterly cleansing/disinfecting everything, I remember TV programmes where they went into people's houses and measured all the "germs" on their kitchen worktop and so on. The idea was to show how revoltingly dirty and unhealthy it was.

Now I'm off to lick my dog.




Dirty Harry




EDIT: walk my dog

Anecdotal also, Mrs. Scott was a teacher and noticed dumpster (bin) divers, who would for instance glean what they could from thrown out watermelon rinds, were healthier than children who's mothers wanted their homes (and children) antiseptic.

[Yodean]

Alritey, my li'l bottle of MB from Amazon arrived tonight.

Will follow the time-tested advice to "start low, and go slow" when it comes to new medications and supplements.

Day #1 of MB will be tomorrow.